Thiazolidinediones pronunciation

Thiazolidinedione definition: Collins Dictionary Definition | Meaning, pronunciation, translations and examples

Learn how to say Thiazolidine with EmmaSaying free pronunciation tutorials.Definition and meaning can be found here:https://www.google.com/search?q=define+Th...Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in ...Background Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss.. Methods This study examines the association between the use of thiazolidinediones or other oral antidiabetic drugs and the risk of fracture. This nested case-control analysis uses the UK General Practice Research Database, including case patients with fracture aged 30 ...Peroxisome proliferator-activated receptor- γ (PPAR γ ) agonists such as rosiglitazone and pioglitazone are used to improve insulin sensitivity in patients with diabetes mellitus. However, thiazolidinediones induce fluid retention, edema, and sometimes precipitate or exacerbate heart failure in a subset of patients. The mechanism through which thiazolidinediones induce fluid retention is ...According to the American Diabetes Association, thiazolidinediones (TZDs) are a class of type 2 diabetes drugs that help insulin to work better in the muscle and fat, and they help lower the amount of glucose released by the liver. In other words, they improve the insulin resistance that is at the heart of type 2 diabetes. Here are the two types of TZDs on the market with their brand names in ...The thiazolidinediones / θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn /, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, [1] are a class of heterocyclic compounds consisting of a five-membered C 3 NS ring.Thiazolidinediones (rosiglitazone, pioglitazone) are oral insulin-sensitizing medications used in type 2 diabetes mellitus that reduce glucose with minimal risk of hypoglycemia and potential benefits on atherosclerosis. However, thiazolidinediones can cause fluid retention thereby increasing the risk of heart failure—a common complication of ...Thiazolidinediones synonyms, Thiazolidinediones pronunciation, Thiazolidinediones translation, English dictionary definition of Thiazolidinediones. n. Any of a class of drugs …

Pronunciation includes many different ideas and skills. Find out more details in this free lesson. See the full lesson here. Try Your First Online Class With A Teacher. Book your first class for just 8.99 USD! Try A Class . Weak Forms in English – Video.INTRODUCTION. The thiazolidinediones increase insulin sensitivity by acting on adipose, muscle, and, to a lesser extent, liver to increase glucose utilization and decrease glucose production. Two thiazolidinediones (rosiglitazone and pioglitazone) are currently available in the United States. In 2010, the European Medicines Agency suspended ...The effects of thiazolidinediones in exacerbating CHF have been detailed in a previously published American Heart Association/American Diabetes Association scientific statement. 39 A meta-analysis by Lago et al 9 demonstrated a 1.7-fold increase in risk of CHF with thiazolidinediones, with a slightly greater increase in risk with rosiglitazone ...How to say Thiazolidinediones। in Hindi? Pronunciation of Thiazolidinediones। with 1 audio pronunciation and more for Thiazolidinediones।.Specific Thiazolidinediones Inhibit Ovarian ... Thus, it is possible that CGZ and TGZ cause a more pronounced effect on the AKT/mTOR pathway than Rosi and Pio.Thiazolidinediones (TZDs) act as insulin sensitizers which activate peroxisome proliferator-activated receptors (PPARs), a broad family of nuclear receptors. The first TZD drug, troglitazone, was approved by the FDA in 1997; however, it was discontinued in 1999 due to severe hepatotoxicity. Currently, there are two marketed TZDs, rosiglitazone ...

If treatment is not started early, it is too late to reverse any damage once symptoms become more noticeable. Treatments for Type 2 diabetes include: Metformin. Sulfonylureas. Meglitinides. Thiazolidinediones. DPP-4 inhibitors. …noun. bi· gua· nide (ˈ)bī-ˈgwän-ˌīd, -əd. : a strong base C2H7N5 that is soluble in water and alcohol. also : any of various derivatives of this base including some (such as chlorhexidine) that are used as antiseptic and disinfecting agents and others (such as metformin) that are used in the treatment of type 2 diabetes see proguanil.Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti ...Listen to the pronunciation of Arateus and learn how to pronounce Arateus correctly. Chinese (Mandarin) Pronunciation. Chinese (China) Pronunciation. Catalan Pronunciation. Chinese (Hong Kong) Pronunciation.

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Learn how to say Secretagogues with EmmaSaying free pronunciation tutorials.Definition and meaning can be found here:https://www.google.com/search?q=define+S...كيف تعمل أدوية ثيازوليدين ديون Thiazolidinedione؟. أدوية ثيازوليدين ديون هي محسّسات للأنسولين تعمل على مسارات التمثيل الغذائي داخل الخلايا لتعزيز نشاط الأنسولين وزيادة حساسية الأنسولين في الأنسجة ...#2 第2型糖尿病藥物治療新知 thiazolidinedione(TZD)類的胰島素增敏劑(表1)。 最近. 幾年則另有3種不同作用機轉的降血糖藥物上市。胰島. 素的臨床使用已超過80年，但仍是降低血糖最可靠、.Learn how to say Secretagogues with EmmaSaying free pronunciation tutorials.Definition and meaning can be found here:https://www.google.com/search?q=define+S...

Sudden sweating. Fast heartbeat. Blurred vision. Tingling in hands/ feet. Signs of kidney problems. Change in the amount of urine. Dark urine. Swelling in legs/feet. Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects.The bactericidal activity of thiazolidinediones derivatives depends on the nature of substitution on the heterocyclic thiazolidine ring rather than the aromatic moiety . Diabetes is a major health problem today, as approximately 5% of the world's population suffers from diabetes. Type I is prevalent in 10% of diabetes patients and an ...The meaning of LIPOLYSIS is the hydrolysis of fat. Recent Examples on the Web This enzyme increases lipolysis and targets fat stored in the cells. — Larry Carroll, Discover Magazine, 12 Oct. 2022 However, excessive levels of lipolysis could lead to a rancid taste (McSweeney and Sousa 2000; Collins et al. 2003b). — Ashton Yoon, …Dec 12, 2021 · What are Thiazolidinediones? Thiazolidinediones, or TZDs, were first introduced by drugmaker Takeda in the 1980s, but FDA approval for the diabetes treatment came in the 90s. Pronounced thai·uh·zow·luh·deen·dai·ownz, they lower A1c and are often used in combination with other antidiabetic drugs. Also called glitazones, they come under the ... チアゾリジン薬の特徴骨格筋および肝臓におけるインスリン抵抗性を改善し、インスリンの相対的な作用を高めて血糖値を下げる。薬剤自体がインスリンの分泌を促すわけではないので、単独使用で低血糖の危険は少ないという特徴がある。インスリン受容体に作用してインスリン抵抗性を改善 ...Trulicity (also known as Dulaglutide) is a treatment for people with Type 2 diabetes.Website: https://www.myhealthexplained.com/diabetes-information/diabetes...Background: The risk of myocardial infarction, macular oedema and bone fractures associated with thiazolidinediones (TZDs) has been extensively investigated. Objective: The aim of the study was to verify if the analysis of a large spontaneous reporting database could generate early signals on these adverse drug reactions (ADRs) associated with TZDs. Methods: A case/non-case study, restricted ...It is also approved for use in combination with metformin, thiazolidinediones and insulin secretagogues. También está aprobada para usarse en combinación con metformina, tiazolidinedionas y secretagogos de la insulina. When combined with other diabetes drugs, thiazolidinediones may cause hypoglycemia.Subscribe. 132. Share. 51K views 5 years ago. Learn how to say Thiazolidinediones with EmmaSaying free pronunciation tutorials. Definition and …Dulaglutide (Trulicity) Pronunciation - Generic Name, Brand Name, Indication, Drug Class (Top 200 Drugs). Individual Video Flashcards with Audio of the Top 2...10. A 38-year-old female complains of having trouble with conception. It is important to ask the patient to: A. Schedule a date for pelvic exam and Pap smear. B. Chart at least three menstrual cycles. C. Take basal body temperature for 3 cycles. D. B and C. D. B and C.

Technically known as thiazolidinediones (TZDs), the glitazones are a family of drugs used sparingly for the treatment of Type 2 diabetes mellitus. Usage was much more common years ago until concerns about side effects grew, some members of the family were banned, and warnings were applied to the drug class.

thiazolidinediones MOA Peroxisome proliferator activated gamma receptor (PPAR-Y) agonist that will increase gene regulations for carbs and lipid metabolism; therefore increase sensitivity of fat, liver and muscles to insulinThiazolidinediones (TZDs) or Glitazones are an important class of insulin sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for their antidiabetic effect through antihyperglycemic, hypoglycemic and hypolipidemic agents. In time, these drugs were known to act by …Translation of "thiazolidinediones" into German . Glitazone, Thiazolidindione, thiazolidindione are the top translations of "thiazolidinediones" into German. Sample translated sentence: Improved method for producing thiazolidinediones, and new thiazolidinediones ↔ Verbessertes verfahren zur herstellung von thiazolidindionen und neue thiazolidindioneDipeptidyl peptidase 4 (DPP-4) inhibitors are a group of antihyperglycemic medications used to manage type 2 diabetes mellitus, which is a significant risk factor for coronary disease, heart failure, stroke, and many other cardiovascular conditions. This activity reviews the various drugs in this group, indications, contraindications, activity, …thiazolidinediones MOA Peroxisome proliferator activated gamma receptor (PPAR-Y) agonist that will increase gene regulations for carbs and lipid metabolism; therefore increase sensitivity of fat, liver and muscles to insulinThe thiazolidinediones (TZDs), pioglitazone and rosiglitazone, are peroxisome proliferator-activated receptor γ (PPARγ) agonists that were developed as oral medications for the management of type 2 diabetes mellitus, although safety concerns have dogged both agents in recent years.Thiazolidinediones may improve metabolic complications in partial lipodystrophy but should only be used with caution in generalized lipodystrophy according to guidelines. In patients with partial lipodystrophy, thiazolidinediones have improved HbA 1c , triglycerides, liver volume, and steatosis, but may increase regional fat excess [ 82 ].Thiazolidinediones—often called TZDs or glitazones—can lower your insulin resistance. This medication helps your body use insulin better, ... Thiazolidinedione(TZD)類. 降血糖藥物新警訊. 張簡麗真藥師. Thiazolidinedione（TZD）類降血糖藥為胰島素增敏劑（insulin sensitizer）。主要的作用機轉. 是經由刺激 ...genesis definition: 1. the origin of something, when it is begun or starts to exist: 2. the first book of the Bible…. Learn more.

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Also called glitazones, thiazolidinediones are oral diabetes medications. These oral hypoglycemic drugs are specific to type 2 diabetes. However, some doctors prescribe them for "off-the-label ...However, it was to some degree inevitable that the thiazolidinediones would be rapidly recognized as having vasculoprotective properties beyond glycemic control that might also be beneficial. First, diabetic complications are vascular in nature, the earliest feature of these is endothelial dysfunction. Second, it is being increasingly ...The authors conclude that, "thiazolidinediones can cause or exacerbate heart failure and pulmonary edema and should be avoided in patients with left ventricular dysfunction or chronic renal insufficiency.". If TZDs cause peripheral or pulmonary edema, does the drug "cause" HF or "exacerbate" preexisting subclinical HF?Create lists of up to 15 entries, like this: cat;cart;cut;caught etc. There are currently 181987 entries in the dictionary.Two such drugs, rosiglitazone and pioglitazone, belong to the class called thiazolidinediones (TZDs) ().Troglitazone, the first agent of this class to be approved, was effective in controlling glycemia but was removed from the market because of serious liver toxicity.1. Introduction. Five-membered heterocyclic molecules containing thiazole nucleus with carbonyl group on fourth carbon such as rhodanine and 2,4-thiazolidinedione derivatives have broad spectrum of pharmacological activities. In past two decades, rhodanines and 2,4-thiazolidinediones have emerged as potent antidiabetic agents.Thiazolidinediones (TZDs) are a class of drugs used for treatment of type 2 diabetes. However, the therapy with currently available TDZs (e.g. rosiglitazone) is associated with important side effects, such as edema and weight gain, suggesting that the investigation of alternative TZDs with better pharmacological properties is warranted.As thiazolidinediones are PPAR-γ agonists, it has been postulated that thiazolidinediones may increase adipocyte differentiation at the expense of osteoblasts in vitro 111, 112. However, in the adult skeleton osteoblasts represent less than 10% of the overall cell population which is mainly composed of osteocytes 110 .Thiazolidinediones / pharmacology* Substances Antioxidants Chelating Agents Free Radical Scavengers Free Radicals Phenols Thiazolidinediones thiazolidine-2,4-dione Grant support PCD 7690/68/15.04.2016, 5200/59/01.03.2017, 3067/4/01.02.2018, 1526/39/18.01.2019/"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania ...We would like to show you a description here but the site won’t allow us.thiazolidinediones MOA Peroxisome proliferator activated gamma receptor (PPAR-Y) agonist that will increase gene regulations for carbs and lipid metabolism; therefore increase sensitivity of fat, liver and muscles to insulin ….

Glimepiride side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Glimepiride may cause serious side effects. Call your doctor at once if you have:Initial: 2.5 mg (McCulloch 2019) to 5 mg administered once daily with breakfast or the first meal of the day. Titration: Adjust dose based on glycemic control; one study allowed dosage increases in 5 to 10 mg increments once weekly (Berelowitz 1994) Maximum dose: 20 mg/day. Patients already maintained on glipizide who require …It was shown [12,13] that transposition of the benzyloxy group to the adjacent 3-position on the central aromatic ring had little effect on the PMT1 inhibitory activity.However, 3,4-bis(benzyloxy) substitution resulted in a significant increase in activity, both against the enzyme and C. albicans cells (IC 50: 2.3 and 3.01 µM).Several compounds have been identified which inhibit C. albicans ...characteristic, while for 2,4-thiazolidinediones, two peaks. occur in this region. The presence of unsaturation at the. 5-carbon atom produces a bathochromic shift due to. conjugation with the C ...Have we pronounced this wrong? Teach everybody how you say it using the comments below!!Looking to study English? Find the best deals on English courses at h... The thiazolidinediones (TZDs) (rosiglitazone and pioglitazone) are activated receptor gamma (PPAR-γ) antidiabetic agents, and are mainly metabolized by liver. They do not require dose adjustment in patients with renal impairment 4 , 5 , and may have renal protective effects.Nov 27, 2019 · Thiazolidinediones are now generic and less costly than pharmaceutical company-promoted therapies. Better understanding of the side effects coupled with clear benefits on the components of the insulin resistance syndrome should promote TZD use in treating patients with type 2 diabetes. Types of Thiazolidinedione (TZD/s) The first TZD was introduced in 1997, so this class of Type 2 Diabetes drugs has been around for 20 years. The very first TZD to come on the US market was troglitazone, or Rezulin. After 3 years of use, this drug was taken off the US market due to liver damage associated with its use.How to say Thiazolidinediones in French? Pronunciation of Thiazolidinediones with 2 audio pronunciations, 5 translations and more for Thiazolidinediones.Here are all the possible pronunciations of the word thiazolidinediones. Pick your prefered accent: David US English Zira US English Rate 1 Pitch 1 Popularity rank by … Thiazolidinediones pronunciation, May 26, 2019 · Thiazolidinediones (rosiglitazone, pioglitazone) are oral insulin-sensitizing medications used in type 2 diabetes mellitus that reduce glucose with minimal risk of hypoglycemia and potential benefits on atherosclerosis. However, thiazolidinediones can cause fluid retention thereby increasing the risk of heart failure—a common complication of ... , Learn how to say Exenatide with EmmaSaying free pronunciation tutorials.Definition and meaning can be found here:https://www.google.com/search?q=define+Exena..., Peroxisome proliferator-activated receptor γ (PPARγ) has received significant attention as a key regulator of glucose and lipid homeostasis. In this study, we synthesized and tested a library of novel 5-benzylidene-thiazolidin-2,4-dione (BTZD) derivatives bearing a substituent on nitrogen of TZD nuc …, The effects of thiazolidinediones in exacerbating CHF have been detailed in a previously published American Heart Association/American Diabetes Association scientific statement. 39 A meta-analysis by Lago et al 9 demonstrated a 1.7-fold increase in risk of CHF with thiazolidinediones, with a slightly greater increase in risk with rosiglitazone ..., Thiazolidinediones reduce insulin resistance in the periphery (ie, they sensitize muscle and fat to the actions of insulin) and perhaps to a small degree in the liver (ie, insulin sensitizers, antihyperglycemics). ... It has no pronounced peaks of action, because a small amount of insulin is gradually released at a constant rate over 24 hours ..., Sulfonylureas, thiazolidinediones, and insulin, all of which have little effect except to lower blood glucose levels, are distinctly de-emphasized. (Level of Evidence = 5) Synopsis., Thiazolidinediones (glitazones: rosiglitazone and pioglitazone) Thiazolidinediones (TZDs) work to lower your blood glucose by increasing the muscle, fat and liver's sensitivity to insulin. TZDs are referred to as "insulin sensitizers" and also are blood glucose normalizing or euglycemics, (drugs that help return the blood glucose to the ..., Pronunciation flashcards for the print, e-book, and pharmacology audiobook Memorizing Pharmacology: A Relaxed Approach. More difficult medication names will ..., Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. Toujeo is not for the treatment of diabetic ketoacidosis. It is not known if Toujeo is safe and effective in children under 6 years of age., As thiazolidinediones are PPAR-γ agonists, it has been postulated that thiazolidinediones may increase adipocyte differentiation at the expense of osteoblasts in vitro 111, 112. However, in the adult skeleton osteoblasts represent less than 10% of the overall cell population which is mainly composed of osteocytes 110 ., hypoglycemic drugs; sulfonylureas; thiazolidinediones; incretin mimetics Type 2 diabetes affects approximately 200 million people worldwide, including more than a quarter of elderly living in developed …, Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. Toujeo is not for the treatment of diabetic ketoacidosis. It is not known if Toujeo is safe and effective in children under 6 years of age., Pronunciation flashcards for the print, e-book, and pharmacology audiobook Memorizing Pharmacology: A Relaxed Approach. More difficult medication names will ..., The suggested UK pronunciation of the new covid-19 variant puts an emphasis on a different syllable. A new covid-19 variant called “omicron” entered the global lexicon over the weekend. The variant spooked the markets after its existence wa..., Background: Thiazolidinediones (TZDs) and sulfonamides are important and highly consumption class of antidiabetic drugs having insulin sensitizing and stimulating properties in patients with type 2 diabetes, respectively. Objective: In this paper, some novel benzothiazole derivatives of TZD-sulfonamides were synthesized (I-IV) and evaluated for anti-hyperglycemic and anti-hyperlipidemic ..., Trulicity (also known as Dulaglutide) is a treatment for people with Type 2 diabetes.Website: https://www.myhealthexplained.com/diabetes-information/diabetes..., Thiazolidinediones, a class of medications indicated for the treatment of type 2 diabetes mellitus, reduce inflammation and have been shown to provide a therapeutic benefit in animal models of Parkinson disease. We examined the association between treatment with thiazolidinediones and the onset of P …, The thiazolidinediones do not increase insulin secretion. On the contrary, thiazolidinediones reduce insulin levels acutely, which may be a consequence of improved insulin sensitivity and/or reduced circulating fatty acids (as fatty acids stimulate insulin secretion). In the longer term, thiazolidinediones arrest the, Aims: Thiazolidinediones administration is assumed to be related with an improvement of endothelial dysfunction (ED); nevertheless, previous studies have been inconsistent. For this reason, the present meta-analysis was directed to estimate if thiazolidinediones were related to endothelial dysfunction improvement by using flow-mediated dilation (FMD) measurement., We've got 0 rhyming words for thiazolidinediones » What rhymes with thiazolidinediones? thi·a·zo·lidine·diones This page is about the various possible words that rhymes or sounds like thiazolidinediones.Use it for writing poetry, composing lyrics for your song or coming up with rap verses., Thiazolidinediones and congestive heart failure in veterans with type 2 diabetes. 2011 Mar;13 (3):276-80. doi: 10.1111/j.1463-1326.2010.01348.x. The thiazolidinedione (TZD) class of antihyperglycaemic agents has been shown to improve glycaemic control by improving peripheral insulin sensitivity but may worsen or precipitate congestive heart ..., チアゾリジン薬の特徴骨格筋および肝臓におけるインスリン抵抗性を改善し、インスリンの相対的な作用を高めて血糖値を下げる。薬剤自体がインスリンの分泌を促すわけではないので、単独使用で低血糖の危険は少ないという特徴がある。インスリン受容体に作用してインスリン抵抗性を改善 ..., Avandia contains the active drug rosiglitazone, which belongs to a class of medications called thiazolidinediones. Metformin is the generic version of a drug called Glucophage. Metformin belongs ..., Thiazolidinediones (such as rosiglitazone and pioglitazone) help muscle and fat cells and the liver absorb more blood sugar when insulin is present. missionhospitals.org Las tiazolidinedionas (como, rosiglitazona y pioglitazona) ayudan a los adipocitos y células musculares y al hígado a absorber más azúcar de la sangre cuando la insulina ..., Nov 23, 2017 · Learn how to say Secretagogues with EmmaSaying free pronunciation tutorials.Definition and meaning can be found here:https://www.google.com/search?q=define+S... , Sep 5, 2021 · Dulaglutide (Trulicity) Pronunciation - Generic Name, Brand Name, Indication, Drug Class (Top 200 Drugs). Individual Video Flashcards with Audio of the Top 2... , David M. Kendall, MD. Address correspondence and reprint requests to David M. Kendall, Chief of Clinical Services and Medical Director, International Diabetes Center, 3800 Park Nicollet Blvd., Minneapolis, MN 55416-2699. E-mail: [email protected]. Diabetes Care 2006;29 (1):154-157., Abstract. Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype (PPAR) activators that are clinically used as an insulin sensitizer for glycemic control in patients with type 2 diabetes.Additionally, TZDs exhibit novel anti-inflammatory, antioxidant, and antiproliferative properties, indicating therapeutic potential for a wide variety of diseases associated with ..., Thiazolidinediones synonyms, Thiazolidinediones pronunciation, Thiazolidinediones translation, English dictionary definition of Thiazolidinediones. n. Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes. , Thiazolidinediones (TZDs) are a new class of oral antidiabetic agents. They selectively enhance or partially mimic certain actions of insulin, causing a slowly generated antihyperglycaemic effect in Type 2 (noninsulin dependent) diabetic patients. This is often accompanied by a reduction in circulating concentrations of insulin, triglycerides ..., In vivo animal studies have suggested that thiazolidinediones (TZD) may be used as disease modifying osteoarthritis drugs (DMOADs). To our knowledge, this has not yet been examined in humans before. The aim was to determine the risk of total joint replacement (TJR) in patients using TZDs compared with diabetic patients using other antidiabetic ..., To clarify the target phase of thiazolidinediones, which are ligands for peroxisome proliferator-activated receptor (PPAR)gamma, during adipocyte differentiation, the effects of a thiazolidinedione, pioglitazone, on every stage during the course of adipocyte differentiation were investigated. Piogli …, Abstract. Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current antidiabetic agents that function primarily by increasing insulin sensitivity. However, despite clear benefits in glycemic control, this class of drugs has ...